Original article: Fludarabine – present status and future developments in chronic lymphocytic leukemia and lymphoma
نویسندگان
چکیده
منابع مشابه
B-Cell Chronic Lymphocytic Leukemia: Present Status and Future Directions
INCE TURKS’ initial identification of chronic lymphoS cytic leukemia (CLL), Minot and Isaacs” description of its clinical features in 1924, and Dameshek‘? hypothesis in 1967, considerable progress in the understanding of CLL has been achieved, especially during the last two decades. The purpose of the present work is to review the major advances in the biology and clinical research of CLL and t...
متن کاملChronic lymphocytic leukemia: present status.
Chronic lymphocytic leukemia (CLL) is the form of leukemia which occurs most frequently in Western countries. Its etiology is unknown, and no relationship with viruses or genes has been demonstrated. Epidemiological data suggest that genetic and ambiental factors might be of some significance. Clinical features of CLL are due to the accumulation of leukemic cells in bone marrow and lymphoid org...
متن کاملChronic lymphocytic leukemia, biology, new diagnosis and treatment: review article
Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
متن کاملTreatment of fludarabine-refractory chronic lymphocytic leukemia.
The development of resistance to purine analogs defines a poor-risk subset of patients with chronic lymphocytic leukemia (CLL). Although in recent years chemoimmunotherapeutic combinations such as fludarabine, cyclophosphamide, and rituximab have induced response rates of 95% in previously untreated patients and increased the rates of failure-free survival, CLL remains incurable for many patien...
متن کاملB-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL.
INCE TURKS’ initial identification of chronic lymphoS cytic leukemia (CLL), Minot and Isaacs” description of its clinical features in 1924, and Dameshek‘? hypothesis in 1967, considerable progress in the understanding of CLL has been achieved, especially during the last two decades. The purpose of the present work is to review the major advances in the biology and clinical research of CLL and t...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1994
ISSN: 0923-7534
DOI: 10.1093/annonc/5.suppl_2.s79